No, there were MS-DOS interrupts for those as well.
BIOS became more relevant for graphics programming as MS-DOS did not do graphics, only text mode.
These became my bibles of the time,
"PC assembly language step-by-step"
https://archive.org/details/pcassemblylangua0000hoff
"Advanced assembly language on the IBM PC"
https://archive.org/details/advancedassembly0000holz
"PC intern system programming : the encyclopedia of DOS programming know how"
https://archive.org/details/pcinternsystempr0000tisc
Last one is great, it has examples on Quick Basic, Turbo Pascal, Turbo C and C++, Microsoft C and C++, TASM and NASM.
The interrupts were used to call bios commands.
The whole DOS was only a tiiiny line between the bios. In fact, I think it really was only “DISK” os.
Edit: https://mrszeto.net/CIT/interrupts.htm
DOS only did file system operations and a few date/time calls