Yup, this is how stuff ends up getting lost and delayed, even if the crews on either side are competent and efficient. Most people can't fill up an 18-wheeler, so some bin packing has to take place for the long haul.
I've done a couple of cross-country moves with a full house and had fairly good luck -- North American Van Lines if anyone is interested -- and by far the best experience was when my stuff was last into the truck making the long distance trip. It was delivered a few days later by the same truck and driver. Nothing was lost or broken. There was no chance to screw things up with intermediate transfers to depots.