I found it disappointing that they ignored one of the biggest problems in the field, i.e. distinguishing between causal and non-causal variants among highly correlated DNA loci. In genetics jargon, this is called fine mapping. Perhaps, this is something for the next version, but it is really important to design effective drugs that target key regulatory regions.

One interesting example of such a problem and why it is important to solve it was recently published in Nature and has led to interesting drug candidates for modulating macrophage function in autoimmunity: https://www.nature.com/articles/s41586-024-07501-1