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Enginerrrdyesterday at 3:25 PM7 repliesview on HN

In case anyone was curious like me: the standard deviation of lifespan is ~12-15 years in developed countries.

So environmental effects, sleep, diet, lifestyle, etc (I.e. modifiable factors) maybe account for half of that, so like 6-7.5 years of variance. Which… sounds about right to me.


Replies

lm28469yesterday at 3:27 PM

Lifespan is not even half the story though, health span is much more important. Your life is completely different if you can ski or split your own wood at 80+ vs being barely able to use stairs at 50. Both might die at 90 but one "lived" 30 years more

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D-Machineyesterday at 5:39 PM

It is almost never reasonable to assume normality and make calculations like this. This is particularly the case when you are dealing with lifespan, which isn't normally-distributed even in the slightest. The actual ranges are likely smaller than you are stating here, and variance is just not a very practical or interpretable metric to use when dealing with such a skewed distribution.

We should be stating something like a probability density interval (i.e. what is the actual range / interval that 95% of age-related deaths occur within), and then re-framing how much genetic variation can explain within that range, or something like it. As it is presented in the headline / takeaway, the heritability estimate is almost impossible to translate into anything properly interpretable.

https://biology.stackexchange.com/questions/87850/why-isnt-l...

DavidSJyesterday at 5:10 PM

One note: the standard deviation of the remaining effects would be sqrt(1/2) as large, not 1/2 as large. So more like 8.5-10.5 years.

its_ethanyesterday at 3:29 PM

This is a nice example/re-stating of what the heritability % "means" here.

I'm curious, with something like smoking/drinking, how you can be confident that you've untangled genetic predispositions to addiction or overconsumption from those "modifiable factors". I guess that's just captured within the 50% heritability? And if you could confidently untangle them, you might find heritability is higher than 50%?

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rzmmmyesterday at 10:14 PM

Environmental effects are not necessarily modifiable. It includes randomness, background radiation, unknown risk factors, anything which is not genetic.

zahlmanyesterday at 3:58 PM

> the standard deviation of lifespan is ~12-15 years in developed countries.

That seems rather higher than I would have expected, at least if one corrects for preventable accidents and other such things (that I would expect to shift the results away from a normal distribution).

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UltraSaneyesterday at 3:29 PM

Lifespan isn't as important as healthy lifespan. Lifestyle can mean the difference between being able to complete an Ironman triathlon at age 80 vs being bedbound.