> (ones you run on beefy 128GB+ RAM machines)

PC or Mac? A PC, ya, no way, not without beefy GPUs with lots of VRAM. A mac? Depends on the CPU, an M3 Ultra with 128GB of unified RAM is going to get closer, at least. You can have decent experiences with a Max CPU + 64GB of unified RAM (well, that's my setup at least).