There are a few interesting points in the comments here.

The pro case for getting rid of frameworks: they're bulky, complex, there are security holes, updates to keep up with, things keep changing. LLMs can write you something perfectly customized to what you're doing. You get some free security by obscurity.

The con case: LLMs are excellent at getting you up to speed with a framework and understanding issues. As avidiax says in this thread, "The author seems to mistake having to update Node.js for a security patch to be a curse rather than a blessing. You get the privilege of patching Node.js." Security by obscurity is generally a bad design. To me, the general architecture and maintainability is a huge issue when you have LLMs write everything from scratch. Not that a Node or React app is a paragon of maintainability or architecture, but it's certainly better than something made from scratch by an LLM. The code quality of a framework is also far higher.

I personally feel like the best path today is to use something lightweight, like Svelte. You get the best of both worlds. Light structure but nothing overbearing.