It's easy if you can build some kind of machine like what Eric Drexler talked about that could manufacture absolutely everything. Otherwise it's impossible.
The best hope for that is to send the one thing to Mars that people absolutely refuse to send to Mars which is bacteria and yeast and microbes. That could be a synthetic biology platform that could make pretty much all the molecules you need and then you assemble them with 3D printing or something like that.
We could send ten thousand workshop machines, a thousand huge forges and presses and reactors, and enough people to run them and all the farms and chemical vats they use those machines to build. Is that not enough manufacturing capability?