Yes, but it doesn't even need mysticism or duality.

There's a more straightforward problem, which is that all of science is limited by our ability to generate and test mental models, and there's been no research into the accuracy and reliability of our modelling processes.

Everything gets filtered through human consciousness - math, experiment, all of it. And our definition of "objective" is literally just "we cross-check with other educated humans and the most reliable and consistent experience wins, for now."

How likely is it that human consciousness is the most perfect of all possible lenses, doesn't introduce distortions, and has no limits, questionable habits, or blind spots?