I know you’re making fun of baseless skepticism here but I remember seeing at least three different “miracle weight loss drugs” hit the market, give people fantastic results, and then get pulled years after some terrible long term side effects. I also remember similar marketing around SSRIs like Paxil being miraculous and GPs prescribing them to teenagers, and that did not go well for teenage me. So forgive me if I’m a little skeptical here.

Teenagers and people in their 20 don’t need these drugs anyway, and they’re the ones who should be most concerned about long term effects.

But people in their 50s and older? What long term effect is going to show up before they die? At age 70 or 80 long term effects are basically completely irrelevant.

Good point. Perhaps if you take them for 40 years, you become biologically immortal. Who can really say?

I think this is FUD. Haven't GLP-1s been around for 20+ year? The recent surge in popularity was due to new formulas that could be injected once per week instead of daily.

Okay I confess to getting taken by this comment. I downvoted and retracted. Sometimes sarcasm is too close to widely held beliefs.

I can't tell if this is a sarcastic response in bad taste, or if it's an authentic, if misguided, opinion.