My wife has had an autoimmune disease that’s caused inflammation for years. Absolutely terrible back pain. She had to rent a motorized scooter when we went to Disney World, and could barely walk a few hundred feet before having to stop and rest for years.
Last year she started Zepbound (tirzepatide) and the inflammation went away, we went to Disney World again and she walked happily all day. Absolutely life changing. She didn’t even lose much weight and this was at the lowest dose.
Tirzepatide specifically seems especially beneficial, likewise here. Years of slowly increasing symptoms since I was young, lifelong annoying issues, basically all gone on it. And also not overweight at all, I take below lowest dose and skip most weeks now that it's under control.