Look at what she has to say.

It is of profound significance.

And sadly, so many of the main cast are no longer with us—far more than one would expect from their ages.

I know that some of them, indeed, died due to substance abuse issues; I don't know the circumstances of all of them. They will all be greatly missed.

They are actors, young people paid to display exaggerated emotion while living in a world that values youth and appearance over everything. Then we ask them to constantly adopt new characters and shower them with on-again off-again false praise based on whether or not they are working on a given day. Frankly, i am impressed that any of them manage to walk away without profound mental health issues.