No because the syntax is so awful. Programming languages are consumed by machines but written by humans. You need to find a middle ground that works for both. That's (one of the reasons) why we don't all program in assembly any more.
Lisp and similar are just "hey it's really easy to write a parser if we just make all programmers write the AST directly!". Cool if the goal of your language is a really simple parser. Not so cool if you want to make it pleasant to read for humans.
I've never used a Lisp either, but I get the impression that "forcing you to write the AST" is sort of the secret sauce. That is, if your source code is basically an AST to begin with, then transforming that AST programmatically (i.e. macros) is much more ergonomic. So you do, which means that Lisp ends up operating at a higher level of abstraction than most languages because you can basically create DSL on the fly for whatever you're doing.
That's my impression, at least. Like I said, I've never actually used a Lisp. Maybe I'm put off by the smug superiority of so many Lisp people who presume that using Lisp makes them better at programming, smarter, and probably morally superior to me.
As someone who writes a lot of Scheme, I agree that the math syntax is not good. There have been proposals to add infix expressions (https://srfi.schemers.org/srfi-105/) but nobody seems to want them, or can agree on specifics.
However, code that is mostly function calls is fine for me, since those would have parentheses anyways in C++/Rust/whatever. In that case it makes the language more regular, which is nice for writing macros.
I'd be curious to hear your opinion on wisp (https://srfi.schemers.org/srfi-119/srfi-119.html) and the Readable project (https://srfi.schemers.org/srfi-110/srfi-110.html) which are significant indentation syntaxes for Lisp languages that are still closely related to the AST and allow for easy macro writing.