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8crazyideastoday at 7:29 PM0 repliesview on HN

Sorry, but the test hasn't been shown to be 94.5% accurate. The study was structured as: 1. neurologist makes clinical diagnosis using usual tools and records most likely diagnosis and their confidence in it 2. new p-tau test is done. 3. neurologists reassess their confidence, and change their mind in many cases. There is no "gold standard" here (tough to have in AD) and not even a period of clinical follow-up to assess for any interval change. The study shows that patients got reclassified, but never showed that such reclassification was more accurate than the initial one, and by how much. There is an implication that because in a different, retrospective study the test did show some accuracy, that it would be helpful in this new situation. But that's about it, and different than directly showing this to be the case.