Meanwhile, the corresponding "non-standard" desktop PC is the Framework Desktop, which with the Ryzen AI Max+ 395 can use 120GB of its 128GB RAM for the GPU: How to Run a One Trillion-Parameter LLM Locally: An AMD Ryzen™ AI Max+ Cluster Guide https://www.amd.com/en/developer/resources/technical-article...
Minisforum MS-S1 is the same chip but has a PCIe slot suitable for a network card.