I fondly remember the browser in F-script Anywhere was fantastic for debugging your own apps and reverse engineering other people's.
Smalltalk is how computing should have been: an open book. I hope that one day we can rediscover that magic, we surely have the computing power available to do so.
Longtime HN user morphle, who commented elsewhere in this thread, has researched and designed chips and hardware for that purpose (edit: for scaling that form of computing). He has been trying to find funds and partners to bring them to market.
Disclaimer: never met or spoken or worked with him