alt Hacker NewsCFFI is fast on PyPy. The JIT still cannot peer into the compiled C/C++ code, but it can generate efficient interface code since there is a dedicated _cffi_backend module built into PyPy. Originally that was the motivation for the PyPy developers to create CFFI.
Thank you for the background info, and sorry for me explaining CFFI (I just wanted to be sure we were talking about the same thing). Being ignorant about PyPy, I honestly had no idea until now that there was a personnel or purpose overlap between CFFI and PyPy. I am very grateful for CFFI (though I only use it API mode).