Sure, that's basically just intonation (JI). You pick what key you want to play in and a scale, and then you build an instrument around that scale.

(Though something that happens in just intonation is that you often find out you need more notes than you might have originally thought, because JI makes distinctions between notes that are treated as the same in 12-TET. For instance, you might have 10/9 or 9/8 as your major second, or your minor seventh might be 9/5, 16/9, 7/4, or 12/7 depending on context.)

I don't think any just intonation guitar has been mass produced, but you can definitely build one or modify an existing guitar if you have the right tools and are willing to do a bunch of math and learn how to install frets.

This page is about a JI keyboard I built a while back, but there's also a few pictures of a couple old Harmony guitars I adapted to JI: https://jsnow.bootlegether.net/jik/keyboard.html

Here's a so-so performance of myself playing a Bach piece on a newer and vastly improved version of that just intonation keyboard: https://www.youtube.com/watch?v=rqbWnDhip0A

In 12-EDO the song has 11 distinct pitch classes. (Bach used the tritone, but not the minor second.) In my straightforward JI interpretation, I use 15 pitch classes. (I would have used 16, but my keyboard simply doesn't have a key for that note.)