If you look at the V-22 safety record in the context of the level of technical development, it is pretty good (e.g. compare to helicopters and aircraft from the 60s). The first production generation of a brand new type of vehicle is always going to be complicated, and virtually all of the V-22 mishaps come from the "new" components and procedures.

The fundamental tradeoff with tiltrotor platforms is that you trade significantly increased speed for significantly increased complexity. What that means is your battlefield survivability goes up when dealing with any opponent with meaningful air defenses, but at the cost of increasing your "resting" accident rate when most peacetime accidents are consequences of maintenance and/or procedural issues.