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systemsweirdyesterday at 1:05 AM2 repliesview on HN

I think mainstream is mostly looking at the microbiome stuff wrong. Your microbiome is the downstream proxy of good lifestyle habits, not generally something to directly manage. Good diet, exercise, reducing stress, and sleeping well will improve digestion and all the downstream variables like microbiome, physical health, and mental health.

This is basic ecology, the bacterial population dynamics in your colon are a direct result of substrate availability. If it’s primarily fiber, polyphenols, and other indigestible plant compounds reaching the colon you’ll likely have a healthy microbiome. If instead you malabsorb food from poor lifestyle factors and have macronutrients reaching the colon they’ll probably fuel blooms of pathogens. I think microbiome researchers need to talk with ecologists more to help advance the field out of the myopia it’s in.

FMT does appear useful for special cases of infection like c-diff, but I think that’s led people to believe it’s a generally health promoting practice, when the research simply does not show it.


Replies

randusernameyesterday at 2:46 PM

I like this measured take, but I think we can also expect it to be a virtuous cycle.

Sure, you have to put in a lot of effort to get the system starting, but eventually the feedback loop pays dividends that outweigh the principal.

Everything else about the human body seems to be this way, adaptation or maladaptation.

adaptbrianyesterday at 2:14 AM

It certainly anecdotal, but feels like you can positively effect your gut microbiome for example by riding a horse. Ive read research about how other mammals can share their microbiomes with humans, if its not the horses biome then what is it that so satisfingly calming post ride. Would love to be enlightened. Ride a horse if you need to destress, amazing creatures.

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