I stopped taking esomeprazole after being on it for 4 years, and frequently had to supplement with famotidine and tums anyway.

I had an infection and was prescribed antibiotics, and needed to pause the esomeprazole. I asked gemini about it and it suggested I take two probiotics while on the antibiotics, Saccharomyces boulardii and Lactobacillus rhamnosus GG. I noticed after a few days that I wasn't getting heartburn, and started putting the pieces together.

After the antibiotics ended, with still no heartburn, it recommend I add rhamnosus gg to the mix. So now I take all three daily and rarely get heartburn. It's been quiet a shock