Look at the history of Lotus Notes ( https://en.wikipedia.org/wiki/HCL_Notes#History )Development began in 1984. 64MB was large back then, maybe 64GB total was seen, but multiples of 64GB?
I guess Lotus/IBM decided to stop upgrading Lotus Notes as computer limits were increased.
Obligatory Damien Katz Lotus Notes Formula Engine Rewrite (it is a great story but also shows the limits the original devs had to deal with; n.b. scroll down to read Ray Ozzie's comment): see https://web.archive.org/web/20050110035626/http://damienkatz...
I don't remember the details but IBM did increase the Domino file size limit a couple of times. The original limit was even smaller than 64GB. Eventually they gave up and stopped investing in the platform so after a few years it fell hopelessly behind advancements in storage hardware technology.