Yes! After many years of using only linux or windows machines, I was assigned an iMac at an internship and noticed the friction with fullscreening things. I decided not to fight it and spent the next year happily working in little windows and making frequent use of the "mission control" gesture.

However, after the internship I went right back to fullscreen/window tiling in linux, so I can't say I really preferred it. Even now as a Gnome user with a big monitor and magic trackpad on my desk - which gives me ~equal access to either approach - I fullscreen everything.