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prplfshtoday at 2:38 PM3 repliesview on HN

https://www.astrazeneca.com/what-science-can-do/topics/next-...

AstraZeneca is doing some really interesting research in this area - cell therapies that reset the immune system to eliminate the dysfunctional cells driving autoimmune disease, and then allow a healthy immune system to rebuild (for diseases like lupus, rheumatoid arthritis, and multiple sclerosis).


Replies

konschuberttoday at 2:48 PM

Today, there is also AHSCT.

There are already clinics where they basically remove your immune system and give you a new one. If you don’t die in the process, you are likely to be cured of MS.

(Any existing damage will remain.)

Currently this is reserved for the most quickly progressing cases but if we can make this safer and cheaper, it might in future be applied as an early stage cure, so people can go on to live healthy lives.

That being said, Astra Zenecas approach does seem much safer, if it’s proven to be effective!

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SmellTheGlovetoday at 3:27 PM

It would be amazing if this type of treatment worked out. MS in particular seems to be a race between technology and your immune system. You hope the next cutting edge treatment is ready by the time the current state of the art stops working for you.

mjleetoday at 3:06 PM

Anokion (now bankrupt) also seemed to have some progress along these lines (link below).

A close family member suffers from MS and is on the more effective but less safe drugs available. They haven’t suffered a relapse since starting them four years ago, but they have been hospitalised twice as a result of side effects.

As we learn more about the relationship between the immune system and various seemingly unrelated diseases the research and understanding has massively increased over the last few years. I’m cautiously optimistic that better treatments aren’t far away. An ancestor was lobotomised for hysteria in the 1960s, before being diagnosed with MS.

https://clinicaltrials.gov/study/NCT04602390