There is a LOC (Loss of Crew) number that is typically calculated for these missions. I'm curious what that is? Early Apollo missions were on the order of 4%.
After the moon landing, Armstrong allowed that he had estimated the survivability at 50%.
In 2014 an independent safety panel estimated 1:75, but I think it's slightly better now. The shuttle program officially had a limit of 1:90 but in practice achieved 1:67.
Before the Apollo launch, von Braun was asked what the reliability of the rocket was. He asked 6 of his lieutenants if it was ready to fly. Each replied "nein". Von Braun reported that it had six nines of reliability.