Is there any reason to think that freshly squeezed juice is chemically different from, for example, frozen juice concentrate?
There is reason to think the differences are biotic vs. abiotic, between the two. Our digestive system is dependent on healthy microbiota. Pasteurization would be the difference here.
From the Wikipedia page on orange juice:
> Commercial orange juice with a long shelf life is made by pasteurizing the juice and removing the oxygen from it. This removes much of the taste, necessitating the later addition of a flavor pack, generally made from orange products.
https://en.wikipedia.org/wiki/Orange_juice