I don’t know the mechanism, I think ME/CFS is an autoimmune condition and semiglutide appears to help with autoimmune conditions in general. That was my reason for trying it. The improvements snuck up on me after many months as I noticed I was having fewer and fewer bad days.
If you felt improvements with semiglutide only after many months, how long did the other trials last? It sounds like you went through hundreds of trials. Did they all went on for many months? When did you determine that a drug wasn't effective and abort the trial? How come you didn't abort the semiglutide trial earlier?