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malfistyesterday at 3:50 PM1 replyview on HN

> Collagen peptides, ghk-cu, and many other peptide supplements are often taken orally.

And with very rare exceptions, it's as useful as watching someone workout when you want to gain muscle. Every meat we eat is awash in peptides, and to keep our body from getting hijacked by the signaling for, say a chicken, our body has to break down almost all peptides ingested orally.

There are a few exceptions, notably there's one that is produced by our own bile acid, that can be taken orally, and then SNAC, which was developed by Novo Nordisk over thirty years and has extremely limited capabilities and is fully patented and cannot be made by your fly by night distributers. SNAC achieves a whopping 1% bioavailability of the peptide, and it's ability to work depends on the size of the peptide, specifically the only commercially available use for this is Rybelsus.

Oral peptides are snake oil for the most part.


Replies

staticassertionyesterday at 5:41 PM

> And with very rare exceptions, it's as useful as watching someone workout when you want to gain muscle.

Who cares? I never made broad claims about their efficacy, the author did.

> Oral peptides are snake oil for the most part.

The author's claim is not nuanced by "for the most part", that's why I quoted it directly.

Besides, I was merely clarifying what the other poster was likely referring to.