I use c-q for prefix key because it doesn’t conflict with common zsh and vim bindings.
Because the author suggested swapping caps lock and control key, I also recommend mapping escape key at the control key and change the behavior based on whether another key is pressed. For example, if you press control + a, it sends c-a, but if you only press control key and then release, it sends escape. It makes your vim life (and in general) a lot easier. You don’t have to compete the most variable real estate on the keyboard, right next to the A key.
For most bindings like moving, resizing, and splitting,I emulate vim bindings.
Also, -r flag for bind-key command is impotent, because it enables to repeat commands like changing the pane size or move focus. You don’t have to press prefix key each time.
If you want to get fancy look with minimal setting, use plugins like nord tmux theme.