alt Hacker NewsI call BS. Wickard is about, effectively, "police power" based on a broad interpretation of the scope of federal/interstate commerce.
As noted by other commenters, the concept of federal control of interstate commerce was intended to prevent states from interfering with trade between themselves and other states, and to create some "higher" authority for aspects of commerce that truly transcended state borders and control.
Most of what has happened in terms of programs and regulations fits very comfortably into that understanding. What doesn't, which I don't think is a lot, should probably go away anyway.
If you can use the commerce clause to prevent a guy growing wheat on his own property and feeding that crop in its entirety to his animals, there literally isn't an activity the federal government can't regulate.