If anyone considers that outcome to be strange - that's how most things are supposed to be regulated. It's doubly specified in the wording of the constitution and 10A.

If one takes the opinion interstate commerce means buying, selling and transporting.

It's also how the current system works. Most drug convictions are based on state law. Federal drug prosecutions are 2% of the total. Every state has its version of controlled substances act.

Nothing much would change at all.