alt Hacker NewsNot appreciably, and not before a 5-yr AppleCare+ warranty expires.
Out of our >3000 currently active Apple Silicon Macs, failures due to non-physical damage are in the single digits per year. Of those, none have been from production systems with 24/7 uptime and continuous high load, which reflects your parenthetical.
Perhaps we haven't met the other end of the bathtub curve yet, but we also won't be retaining any of these very far beyond their warranty period, much less the end of their support life.
I think the point of this is more "use the machine you have at home" than "do a TCO analysis and see if it's profitable", though. People like to keep their machines working for longer, generally.