I was comparing various models at M5 Pro 48GB RAM MLX vs GGUF and found that MLX models have a higher time to first token (sometimes by an order of magnitude) while tokens/sec and memory usage is same as GGUF.

Gemma 3 27B q4:

* MLX: 16.7 t/s, 1220ms ttft

* GGUF: 16.4 t/s, 760ms ttft

Gemma 4 31B q8:

* MLX: 8.3 t/s, 25000ms ttft

* GGUF: 8.4 t/s, 1140ms ttft

Gemma 4 A4B q8:

* MLX: 52 t/s, 1790ms ttft

* GGUF: 51 t/s, 380ms ttft

All comparisons done in LM Studio, all versions of everything are the latest.