For sure. These are often people who want better equipment to do their research, not software subscriptions that promise to force them to work in unfamiliar and uncompelling ways. You'd need a fantastic, game-changing idea to get meaningful traction.

One example of these might be systems like S3 and distributed computing in AWS. Like, huge ideas that take massive initiatives to implement, but make science meaningfully easier. I can't think of many other modern technologies we use that the team doesn't mostly resent (like Slack or Google Drive). They're largely interested in just doing the science, the rest eats into funding (which is increasingly sparse these days).