I would people need to read the #1 post on HN today to get a clue why they are failing with Alzheimer's.

https://www.scientificamerican.com/article/amateur-armed-wit...

Just like that math problem, we are starting off with wrong thinking right from the beginning. Some researchers are already talking about this but the plaques are actually a protective response to a metabolic problem in the brain which has to do with glucose transport.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8772148/

This is why people with dementia and Alzheimer's crave sweets so much:

https://helpdementia.com/why-dementia-patients-crave-sweets-...

Alzheimer's is not a neurological problem, it is a metabolic problem.