alt Hacker NewsYou can really tell from the comments those who didn't read the article and who are taking the headline extremely literally.
He quoted Shakespeare's MacBeth, "It is a tale, Told by an idiot, full of sound and fury, Signifying nothing." when talking about he thinks sketch comedy is the greatest form of self expression, even moreso than poetry from people like Shakespeare.
It's not that deep.
It was forced by the interviewer for a clickbait flair. The headline ought to be "NYT would like to remind you that life is a meaningless farce":
Interviewer: There’s a holistic observation I want to make about our conversation. You talked about how the best times in your life were when your kids were little. Those times are over. You said the art form you love the most, sketch comedy, is a young man’s game. That’s over for you. Life? It’s a farce.
Odenkirk: Yeah.