For my paper about ME/CFS, I let an LLM integrate lots of findings of other scientific papers. Then I ask the LLM to "creatively brainstorm", given all we know of ME/CFS and the newly integrated paper, to generate new hypotheses, treatment ideas or any other kind of insight it can think of.

This works really well.

Now, it's clear that I have no idea how much of this is something we would consider new and original, and how much is a kind of systematic, but not novel, easy of thinking.

What I couldn't do so far is get an LLM to generate a truly new maths theory, with new abstract concepts and dimensions and points of view. The kind that is not just a combination of existing theories and logic.