For the stuff in more sensitive deployments it's really quite simple, just setup CORS etc properly and don't do anything overly fancy on the frontend. Worst case the user may force some internal function to eval some JS by pasting scripts into the browsers debug console.

Critical severity vulnerabilities are only critical when they are reachable, but are completely meaningless if your application doesn't touch that code at all. It's objectively more risky to "patch" those by updating dependencies than just let them be there.