It sounds like this is mostly (or exclusively?) operating directly on AA seqs. I wonder what the upper limit of capability this is for the intended use case. As in, without incorporating the 3d chemistry or spacial reasoning. E.g. classical MD, DFT etc like ORCA performs etc. Of particular interest: Does this upper bound (assuming it exists; I suspect it does) preclude its utility in practical protein design/gen.

I speculate Cradle is taking the approach they are vs structural/spacial, as structure spacial models don't work very well on big molecules like proteins! (And/or are too slow; errors accumulate over space etc)