How you handle employees after the layoff announcement is a much easier conversation: Give them a lot of dedicated resources to navigate it and give them a good parting offer.
Nobody ever seems happy about how the announcement part is done though. "Wait for everyone to have 1:1" and the problem is the mass panic that starts to roll through the workday as employees wonder if they are next. "Mass announce and then engage after" makes another group upset they were told by a generic mass email. I've been at places which have gone each way and I'd honestly rather hear from the mass email myself.