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asdffyesterday at 11:40 PM4 repliesview on HN

Weight would only be regained if you start eating more, no? I would think that would be hard to do if you've already seen what appropriate portions are.


Replies

OkayPhysicisttoday at 12:07 AM

You seem to have a fundamental misunderstanding of what GLP-1 agonists help with. In simple terms, they make you less hungry. If you stop the drugs, it's not surprising you go back to being hungry. It would be a miracle drug if you didn't.

People, on average, eat until they're no longer hungry. Problem is, there's only a loose relationship between your caloric needs and your hunger response. That's how you end up with underweight people who are trying to put on muscle saying they can't possibly eat any more and still can't put on weight, while having overweight people who eat twice as much as that guy and have to actively choose not eat more. Both people can make a conscious choice to disobey their signals, just like how you can choose to hold your hand to a hot stove. But it takes a lot of energy to keep up that willpower. Effective weightloss drugs solve that problem, by treating the actual problem: the hunger.

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rimunroetoday at 12:18 AM

> I would think that would be hard to do if you've already seen what appropriate portions are.

This would be true if not knowing what an appropriate portion size is was the one thing keeping most people from losing weight. If that was the case, traditional dieting would have a far better track record with long term weight loss.

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ChiperSofttoday at 5:04 AM

Nope, the body will adjust to regain it no matter what.

Australia's health organization did a meta study on people who had bariatric surgery. They found that every single one regained 70% of their original weight after five years, even though they were physically incapable of eating the way they did before.

This happened to my grandmother, she had a bypass in the 2000s, lost over a hundred pounds, and then regained it again and was back to her original weight when she passed in 2022. The woman couldn't eat more than 4 ounces per meal without throwing up.

I lost 40 pounds in 2017 from gastritis. I kept it off for three years, and then regained 50 pounds despite starting ozempic.

malwarebytesstoday at 12:41 AM

Except if your body is unnaturally screaming at you to eat more. The obesity epidemic is not caused by ignorance or lack of willpower. It's natural differences in how people's bodies work compounded by modernity's changes to physical activity levels and diet.

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