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arjietoday at 8:03 AM0 repliesview on HN

The magic trick with these is the way to increase half life. It’s really quite an amazing piece of work. I used retatrutide for a while very effectively but then we’ve been traveling a few months and I’ve gained quite a bit of weight back as expected.

The drug is pretty much ideal: dose-response curve doesn’t flatten too much, adaptation is present but not extreme, it is entirely reversible when you get off it.

The side effects I see are a histamine reaction at the injection site and cold sensitivity. To stop the former I varied duration of injection, temperature of solution, and site. None of these had any effect so I just lived with it in a place it wasn’t too uncomfortable.

I haven’t been lifting very much during the period immediately prior due to injury playing sports and reinjury due to inactivity after a motorcycle accident years prior.

My peak lifts were @155 lbs: squat 265x5, deadlift 375x2, bench 185x1, ohp 135x5. Stating these so you know where to baseline.

Immediately prior to retatrutide schedule: squat non functional (could not squat), deadlift 225x5, bench 125x1, ohp non functional (could not raise arms above head). Weight 199.3 lbs And I was also going to physical therapy.

After schedule: squat 135x5, deadlift 325x5, bench 135x10, ohp 135x2. Weight 173 lbs

1.5 months after cessation: I didn’t increase lifts due to not having standard programming. Weight 182 lbs.

Overall, an excellent drug. I should note that I ramped up slowly from under 1 mg/week up so my nausea and other symptoms were extremely minor. At lower doses I’d walk up to the fridge as I did in the past and then decide against eating a snack. At higher doses I wouldn’t get up. I already knew I should drink but I drink a lot of Coke Zero so that was fine. I never actually hit a routine dose that was within the tested range, I was always lower.