alt Hacker NewsWell, parallel port adc capture has nothing to do with PIO either - on STM32 you would just set up DMA on a GPIO port, then capture 16bit data. The real question is what RP2040 is going to do with 120MB/s of data.. and the answer is, it can't process it or send it over (12Mbps aka 1.5MB/s) USB. So, would only work in low duty cycle pulse mode, no streaming.
It is designed for short captures. You can see the practical applications at: https://un0rick.cc/use_cases .
I can assure you these use cases are hard to achieve with a standard STM32 as someone whos almost finished with their PhD in mid-air ultrasonics.