No, it doesn't. In JVM Clojure's case, the vars are usually compiled to the moral equivalent of a global variable holding a pointer to a function. This allows you to update the function if the developer redefines it in the REPL, but it comes at a performance cost (the JVM can't inline it or otherwise optimise it). Clojure also allows you to compile with "direct linking", e.g. for production deployments, where you know you're unlikely to be wanting to dynamically update the code. In those cases defns are compiled down to static methods which call each other - much faster since the JVM can perform its magic with them, but you can't update them at the REPL.

I'm unsure exactly how jank works WRT this tradeoff, but the article makes it sound like it's closer to the direct linking version, but with the inlining etc being done by jank rather than the JVM. I don't know if this is only for AOT or also in JIT cases.