I wrap most node-isms and use deno as the runtime. Works well. If a project is pure typescript I just have deno run it. Extra options for security are great, installation scripts disabled by default, etc.

If you're using node directly, please stop. At a minimum use Bun.

With agentic work, there is little reason to use anything besides Rust and Typescript in any case. Room to disagree but type safety, memory safety, and a large corpus of work is critical. Agents need difficult errors and baked in patterns they navigate it easily. For UI, Typescript makes the most sense just because of the mass of design examples.