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ElijahLynnyesterday at 11:49 PM3 repliesview on HN

It only reduces by 4 events per hour. That seems like it might be helpful for someone with mild sleep apnea. But not with moderate or severe sleep apnea.

Adult AHI Severity Levels

Normal: Less than (5) events per hour.

Mild Sleep Apnea: (5) to (14.9) events per hour (frequent minor interruptions).

Moderate Sleep Apnea: (15) to (29.9) events per hour.Severe Sleep Apnea: (30) or more events per hour.

"By mapping the neural circuits that lead to this common condition, work from the Horner lab laid the foundation for AD109, a new treatment developed by researchers in Boston to specifically target the two pathways that contribute to sleep apnea. The daily oral medication contains two drugs: one that increases noradrenaline levels and another that blocks muscarinic receptors.

In a recently published phase 3 randomized clinical trial, people with mild to severe sleep apnea who received AD109 had less airway obstruction and higher oxygen levels than those who received a placebo. On average, per hour of sleep, participants on AD109 had four fewer events where they stopped breathing or had very shallow breathing."


Replies

MetallicCloudyesterday at 11:57 PM

Yeah, I was excited until I read that. Last time I was tested I had 48 events per hour. 4 wouldn't help me much.

Broken_Hippotoday at 12:38 AM

They say later in the article that the pill is a good option for folks that can't or won't use the CPAP.

A CPAP is really effective, so it would be first line treatment. If I couldn't use one but needed it, I'd be happy to have fewer events per hour than all of it. Improvement is better than nothing in this case. Besides, a lot of drugs are improved after the initial breakthrough drug - so this gives hope that we might actually be able to be free of the CPAP for many more folks.

Waterluviantoday at 12:12 AM

My AHI was 151 when measured. The CPAP has changed my life but I do look forward to any possible way to not need it anymore.

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