As far as visibility is concerned, the only problems I've encountered in a big truck are to do with the driver-side A-pillar obscuring pedestrians about to cross the street on the other side of an intersection. It's the perfect width, and in just the right spot that I've had to stop in the middle of an intersection a few times now because I didn't see somebody as they just started to cross. I'm building the habit of moving my head around at intersections, but I'd spent decades before they changed regulations not having to do this (and it doesn't actually seem that big, but it really obscures a big chunk of arc, especially at "other side of the intersection" distances and greater).

In practice, if somebody is right in front of my grill where I can't see them, they were close enough for me to notice them before they got there without me having to be on high alert for people.

I'm not putting this here as a truck-vs-car thing or whatever, I'm just trying to people a realistic idea of where the blind spits are that actually cause trouble in my experience.