These services run on the blockchain, right? So in effect, there is no blocking them.
You can block the web user interface and effectively block Polymarket for 99.9% of users. No ban is ever 100% effective.
Prison bars are an unpatched DoS vulnerability that affects all blockchains.
Off-ramping to fiat would be criminalised and pursued beyond the wildest dreams of La Liga/Cloudflare. A gambling site you can't withdraw your winnings from is of no interest to anyone.