I'd agree that deregulation is a complete hard no for most people, but that's because removing bad/watered down regulation isn't enough. Calling for "deregulation" is like saying "defund the police". A very small number of radicals claim to actually want that, but most people think that something better has to fill the void. Bad regulation needs to be replaced by good regulation.

If what you mean by "Deregulation" is "different/better regulation" most people will happily support it. For example, most people would love to have the government just automatically mail them their tax refunds with the paperwork they need to verify it was correct. Standing in their way are companies who have been spending a lot of money on bribes to make sure filing our taxes is as expensive and difficult as possible (https://www.nbcnews.com/business/taxes/turbotax-h-r-block-sp...)