Haven't used Apprise, but it looks interesting!
My current plans are for Posthorn to stay focused on email. There's enough work here that I think it justifies a dedicated tool.
I have some v2 roadmap ideas for things like multiple outputs per endpoint so that a contact form submission can fire both an email and a webhook in the same call to support things like form -> email + slack or script triggers an email + pager duty alert.
That's complimentary to the email though, not something I had planned to build out as a stand alone use case. I'd be interested in hearing how that would be useful for you though!
We've chosen Apprise just for the big number of services supported, actually at the moment we only use email and telegram as notification output channels.
Apprise does not accept SMTP protocol as input, so you're bound exclusively to API, binary exec or third party integrations.
I think Posthorn could fill a gap if it will integrate the possibility to send a webhook (alongside/instead of email).