I've commented this many times, but I definitely want to see more isometric grid games like SC3k, RC2 or TTD.
They were less-realistic, yes, but is so pleasant how everything ties together and you can neatly fill out the whole map.
Meanwhile, while I like Cities Skylines or Planet Zoo, it is always incredibly awkward to build roads and paths to the point where I find it frustrating.
it's so frustrating in Cities Skylines without mods, that it's so common difference in height causing so much placement issues
Isometric sims make it easy to build something that looks good. CS & PZ can make things look incredible, but it's a PITA to get there.